BEWARE: Not All Labs Are Created Equal

biopsy under microscopeYOUR SKIN BIOPSY

There is a major epidemic of skin cancer in the world today. In the United States alone, millions of skin cancers will be diagnosed just this year. Furthermore, it is estimated that approximately 1 in 50 individuals born this year will develop malignant melanoma, the most dangerous and often life threatening form of skin cancer in their lifetime. This cancer is the leading cause of death in young women in their 20’s and 30’s. However, skin cancers are most common in older people over the age of 50. Because of the gravity of this problem, it is vitally important that all individuals, especially those in the highest risk groups, understand how to recognize the signs of skin cancer and call it to the attention of their doctor, preferably someone with expertise in skin disorders. If there is suspicion that a spot may be skin cancer, a biopsy must be performed to make a diagnosis before treatment is undertaken. Getting an accurate diagnosis from the biopsy is critical as different treatments are used for different skin disorders and if the lesion turns out to be benign, no treatment at all may be required.

What many patients and surprisingly many doctors, especially non-dermatologists, do not understand, however, is that there is significant variation in the accuracy of different pathology labs depending on who is performing the examination of the biopsy. Many doctors try to reassure their patients that they are “sending the specimen to the lab.” What you should ask your doctor is, “Which lab and who’s going to be reading my biopsy”?

CHANGING TIMES

Years ago and still in many cases today, doctors, especially dermatologists, developed close working relationships with pathologists known as dermatopathologists, who are specially trained to interpret skin biopsies. With the ongoing evolution of health insurance companies, national laboratory companies made bids to provide laboratory services, mainly blood tests, for managed care plan patients. Because health insurance companies often look at all lab services as one, many of the specialized areas of pathology such as dermatopathology, where an expert performs the service, were lumped into the same category as blood tests performed by a machine with no need for physician interpretation. Furthermore, there are cost pressures that discourage non-experts from seeking consultative second opinions from experts.

SERIOUS CONSEQUENCES

A misread specimen can have serious consequences for a patient. Failure to diagnose a skin cancer, especially a melanoma, can result in a disease that can be cured turning into a deadly process. On the other hand, over diagnosis of something benign as a cancer can lead to loss of insurance or significantly increased insurance premiums, not to mention unnecessary and sometimes disfiguring surgery. In some cases, patients simply go for months, sometimes years with no diagnosis or an erroneous one. In addition to poor patient care, inaccurate lab results can lead to legal liability and increased health care costs.

DEPENDING ON EXPERT DERMATOPATHOLOGISTS

The most important key to accuracy involves the expertise of the person who is reading your biopsy. While board-certified dermatopathologists are certainly the best trained to read skin biopsies, some general pathologists with interest and experience in dermatopathology can do a good job, especially if he or she has access to consultation with a board-certified dermatopathologist. In the ultimate analysis, it’s not the label of the person who evaluates the slide that matters but his or her competence, said the late A. Bernard Ackerman, M.D. As a rule, Dr. Ackerman always noted that a board-certified dermatopathologist is best equipped to render an accurate diagnosis of a skin lesion that is difficult to diagnose under the microscope, a phenomenon that is surprisingly common.

CHALLENGING LESIONS

Expertise becomes even more crucial in lesions that are difficult to interpret. Some subtle skin disorders, such as mycosis fungoides, a rare type of skin lymphoma, require very special expertise to make the right diagnosis. Non-cancerous skin diseases due to inflammation such as rashes can be diagnosed accurately only by dermatopathologists. Other challenging diagnoses are diseases that produce blisters such as bullous pemphigoid, pemphigus, and epidermolysis bullosa.

WORRISOME TREND

Some health insurance companies require physicians to send specimens to a specific lab that may or may not have an individual with expertise in dermatopathlogy. Many health insurance have instituted programs to penalize physicians who fail to utilize contracted laboratories, a practice that has received criticism from many physicians across the US. Many dermatologists choose to opt out of contracts in which the biopsies are “steered” to a non-desired lab. They fear that these labs might not provide complete service for their patients and pose a malpractice risk to them.

THE IMPORTANCE OF COMMUNICATION

Communication is another important factor in making sure your doctor gets the “right” answer in your skin biopsy. When your doctor, especially a dermatologist, performs a biopsy, he or she is not sending out a simple blood test to a nameless lab. He or she needs to know who the pathologists are and work with them. Some specimens can present subtleties that are quite difficult to interpret. Arriving at a correct diagnosis requires a good treating physician who can relay information between the doctor performing the biopsy and the pathologist. Lines of communication have to be open both ways so that the doctor can call the pathologist to ask questions about a result, and the pathologist can call the doctor when he needs clinical clarification. Unfortunately, in many labs, it is difficult to reach any pathologist to discuss a case. Furthermore, it is often necessary for a slide to be sent back to the doctor, because the patient is going for a second opinion or for additional treatment. “It is often difficult to get slides from some labs,” notes Dr. Clay Cockerell.

OTHER SIGNS OF QUALITY

High-quality labs perform daily quality control and most perform special studies when required such as immunophenotyping. They also comply fully with state, federal and other regulations. A lab having an accreditation is also a sign of quality because obtaining and maintaining certifications takes time and requires passage of rigorous inspections.

RAISING COMPLAINTS

As many health insurance companies attempt to “steer” biopsies to large corporate labs with which they have a contract, it is quite possible that your doctor is not happy with the quality of the lab but feels compelled to use it nonetheless, especially if there is a risk of a penalty. If you or your doctor is not happy with the quality of service from a lab, a number of different steps can be taken. Generally, the first step is a letter from your doctor and in some cases from the patient addressed to the health insurance company  expressing complaints.

In response, the health insurance company may agree that your doctor can send the specimen to the lab of his choice. Another, although less satisfactory solution, is that your doctor can insist that the lab have on staff a board-certified dermatopathologist. That’s not a substitute, though, for having someone read your specimens whom your doctor knows and trusts.

Finally, another option is for the patient to pay for the biopsy interpretation out of pocket. Surprisingly, however, many patients are reluctant to do so because they feel as if they need to “get their money’s worth” and go with what the insurance plan will pay for, even if the expense is relatively low. Many people have no problem shelling out $100.00 or more for things such as a dinner out on the town; but when it comes to paying for an expert interpretation of a skin biopsy that could save his/her life or that of a family member, they balk.

BOTTOM LINE:

Ask your doctor where he or she would send the biopsy if it was from one of his or her family members. Then request the same for yourself.

From Clay J. Cockerell, MD on LinkedIn: Original Article Here